The 2026 edition marked a defining new chapter for the Milan Longevity Summit. Guided by a One Health perspective, the Summit expanded the conversation beyond medicine and ageing to explore the interconnected systems that shape the future of human health, planetary wellbeing, and long-term prosperity. Over four days, global leaders from science, business, policy, finance, technology, and civil society came together to challenge assumptions, exchange ideas, and build new collaborations across disciplines. MLS26 explored longevity through thirteen interconnected systems, from health and life sciences to food, cities, climate, technology, finance, education, and culture, recognizing that the challenges of our time demand integrated solutions. The result was not simply a conference, but a platform for systems thinking, cross-sector collaboration, and collective action.